Manchester United boosted their chances of making the top 4 with a 2-0 Victory over Wolverhampton Wanderers.
Liverpool had been given hope of snatching a Champions League spot from Erik ten Hag’s side, who had lost to both Brighton and West Ham.
However, Manchester United secured a win with goals from Anthony Martial and Alejandro Garnacho, moving them four points clear of Liverpool with three games remaining.
Meanwhile, Southampton’s 11-year stay in the Premier League came to an end as they were relegated after a defeat at home to Fulham.
Aleksandar Mitrovic, who returned from an eight-game ban for pushing referee Chris Kavanagh, sealed Saints’ fate with a header after Carlos Vinicius’ opener.
In another match, Nottingham Forest fought against Premier League relegation and claimed a valuable 2-2 draw against Chelsea with Taiwo Awoniyi scoring twice.
Aston Vila defeated Tottenham Hotspur by 2-1, while Crystal Palace Defeated Bournemouth by 2-0