The game was witnessed live by 80,000 passionate fans, mostly AC Milan supporters, as Inter dominated the early stages.
Edin Dzeko opened the scoring with a spectacular volley in the eighth minute, silencing the home fans. Henrikh Mkhitaryan doubled the lead just three minutes later after being set up by Federico Dimarco.
Despite Hakan Calhanoglu hitting the woodwork and Inter threatening to extend their lead, AC Milan were given a glimmer of hope when a penalty decision was overturned after consultation with the pitchside monitor.
Inter slowed down in the second half, but their early goals proved enough to secure a memorable victory.
Inter remained resolute and now find themselves in a formidable position to secure a spot in the final.
The Italian side will go on to face either Manchester City or Real Madrid in the finals, pending the outcome of their upcoming second-leg encounter at San Siro on Tuesday, May 16th.